Clinical Trial

Heterogeneity of Oral Carcinogenesis: From PrEneoplasia to Invasive Squamous Cell Carcinoma

Study acronym: HOPES
Not Yet Recruiting
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Summary
The goal of this project is to characterise the heterogeneity of all cell populations (tumour cells, stromal and immune microenvironment) present in the tumor and their normal (and OPMD) counterparts by scRNAseq in OSCC patients. Additionally, the study will evaluate the effectiveness of non-invasive cytobrushes as a diagnostic tool compared to traditional biopsies.
Trial Details
NCT Number NCT07579507
Lead Sponsor Centre Leon Berard
Conditions Oral Squamous Cell Carcinomas, Oral Potentially Malignant Disorder
Enrollment 150 participants
Start Date 2026-06
Primary Completion 2035-03 (estimated)
Study Completion 2035-03 (estimated)
Updated on ClinicalTrials.gov 2026-05-12