Outcomes Tracking in Unilateral Vocal Fold Paralysis (UVFP) and Atrophy After Medialization Laryngeal Surgery

The goal of this observational study is to learn about the long-term outcomes of Laryngeal Framework Surgery (LFS) in patients with Unilateral Vocal Fold Paralysis (UVFP) or Vocal Fold Atrophy (VFA). The main questions it aims to answer are: * Whether LFS technique (implant material, addition of arytenoid adduction) is associated with differences in outcomes such as complication rate, duration of surgery, hospital stay length, and quality of voice post-surgery. * Whether UVFP or VFA diagnosis is associated with differences in outcomes such as complication rate, duration of surgery, hospital stay length, and quality of voice post-surgery. Participants who are determined by their clinician to need LFS for their UVFP or VFA will undergo the procedure, attend follow-up appointments, and complete surveys about their voice and swallowing ability as they would as part of their regular medical care.

NCT Number	NCT07579364
Lead Sponsor	University of California, San Francisco Collaborators: Massachusetts Eye and Ear Infirmary, University of California, San Diego, Wake Forest University, University of Cincinnati, University of Miami, Ohio State University, Washington University School of Medicine, University of Southern California, Medical University of South Carolina
Conditions	Unilateral Vocal Cord Paralysis, Vocal Cord Atrophy
Enrollment	500 participants
Start Date	2025-10-28
Primary Completion	2028-01 (estimated)
Study Completion	2028-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-12