Clinical Trial

Pyogenic Liver Abcess in Guadeloupe

Study acronym: PYG
Completed
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Summary
Liver abscesses are infections of the liver parenchyma, most often bacterial, occurring via the biliary tract, bloodstream, or by direct spread. Although rare, they are serious, with a mortality rate of around 15%. In Western countries, they are mainly polymicrobial or associated with Escherichia coli, streptococci, and Klebsiella pneumoniae. While overall incidence is low, it appears higher in Guadeloupe. There is a growing increase in cases caused by hypervirulent \*Klebsiella pneumoniae\* (hvKp), which can infect healthy individuals and spread to distant sites such as the eye, lungs, and central nervous system. Its virulence is linked to specific genetic factors. The emergence of multidrug-resistant hypervirulent strains represents a major concern. In Guadeloupe, about ten cases per year are reported, with no clearly identified risk factors.
Trial Details
NCT Number NCT07579104
Lead Sponsor Centre Hospitalier Universitaire de la Guadeloupe
Conditions Liver Abscess, Pyogenic
Enrollment 58 participants
Start Date 2021-03-22
Primary Completion 2024-02-15 (estimated)
Study Completion 2024-02-15 (estimated)
Updated on ClinicalTrials.gov 2026-05-11