NotablePrimary endpoints: details revised at 1 of 2 entriesShow 4 more changesShow less
Trial completed
Study completion date changed from estimate of Aug 17, 2026 to Aug 15, 2026
Eligibility criteria revised
Secondary endpoints: details revised at 7 of 7 entries
MinorEnrollment closed, study ongoing
Study completion date: Aug 15, 2026 to Aug 17, 2026
Start date: May 15, 2026 to May 18, 2026
Site details revised
v6
MinorStart date changed from estimate of Jun 2026 to May 15, 2026v5
MinorStart date: May 15, 2026 to Jun 2026v4
MinorPrimary completion date: Jul 22, 2026 to Jul 2, 2026
Study completion date: Sep 12, 2026 to Aug 15, 2026
v3
NotableRecruitment opened
Primary completion moved earlier from Sep 12, 2026 to Jul 22, 2026
Study sites: 0 to 1
v2
MinorStudy First Submitted
Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
Minor: routine progress and housekeeping, such as sites added or enrollment closed.
For this study, the study medicine has been specially prepared to contain radiolabeled carbon \[14C\]. \[14C\] is a naturally occurring radioactive form of the element carbon. Adding a low dose of radiation to the study medicine does not change how the medicine works but helps to see how the medicine appears in the blood, urine, and stool after it is given. This type of study is called a radiolabeled study.
The purpose of this radiolabeled study is to learn how a certain amount of \[14C\] PF-07799544 is taken up into the bloodstream and removed from the body.
The study is seeking participants who are:
Male Ages 18 to 55 years of age confirmed to be healthy based on medical and physical tests.
Weigh more than 50 kilograms (kg) and have a body mass index of 17.5 to 32 kg per meter squared.
The study consists of two parts. In part one, all participants will receive one full dose of \[14C\]PF-07799544 by mouth.
Part two will begin at least 14 days after the dose in part one. In part two, participants will receive one full dose of PF-07799544 by mouth and one small dose of \[14C\] PF-07799544 by intravenous (IV) infusion. IV infusion will be directly injected into the veins.
To understand how the medicine is processed in the body, samples of blood, urine, feces, and vomit (if any) will be collected after each dose is given. This will help understand:
How much PF-07799544 is taken up into the bloodstream when taken by mouth compared to the dose given by IV How the body removes it from the blood steam. Participants will take part in the study for about 7 weeks, including evaluation at the start and follow-up period.