Biomedical Signal Extraction From Symptom Descriptions: An Observational Registry Using the OpenGenome Platform

This registry prospectively collects anonymized free-text symptom descriptions submitted voluntarily by adults through the OpenGenome platform at opengenome.bio. For each submission, the system retrieves real biomedical literature from PubMed and ClinicalTrials.gov in parallel, applies a constrained reasoning model operating under a strict output schema, and returns a structured biological signal report. The study evaluates the internal consistency of extracted signals, the calibration of confidence scores relative to dataset size and symptom specificity, and the distribution of biological signal categories across a large anonymous population. No intervention is assigned. No participant contact occurs. All data is anonymized at the point of collection.

NCT Number	NCT07578610
Lead Sponsor	OpenGenome
Conditions	Signs and Symptoms, Fever, Myalgia, Skin Diseases, Hemorrhagic Fever With Renal Syndrome, Zoonoses
Enrollment	1,000 participants
Start Date	2026-05-05
Primary Completion	2028-05-05 (estimated)
Study Completion	2028-05-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-19