A Research Study Investigating the Effect of NNC0497-0040 in Healthy Participants, Participants With Overweight or Obesity, and Participants With Type 1 Diabetes With Overweight or Obesity

The purpose of this clinical study is to find out if NNC0497-0040 is safe, tolerable and effective for healthy people living with normal weight or overweight, people living with overweight or obesity and people who have type 1 diabetes and are living with overweight or obesity. There are 2 study treatments in this study, where participants will get either NNC0497-0040, the new treatment being tested or placebo, a treatment that has no active medicine in it. Participants will be in this clinical study for up to 29 weeks.

NCT Number	NCT07578584
Lead Sponsor	Novo Nordisk A/S
Conditions	Type 1 Diabetes (T1D), Overweight, Obesity, Healthy Volunteers
Enrollment	146 participants
Start Date	2026-05-07
Primary Completion	2028-02-18 (estimated)
Study Completion	2028-02-18 (estimated)
Updated on ClinicalTrials.gov	2026-06-04