Long-term Follow-up of Dexmedetomidine-esketamine and tDCS for Neurocognitive Complications After Surgery

Neurocognitive complications, mainly delirium and neurocognitive disorders, are common cerebral complications in older patients after surgery and associated with worse long-term outcomes. An ongoing 2×2 factorial trial conducted by the investigators plan to test the effects of perioperative dexmedetomidine-esketamine combination and transcranial direct current stimulation (tDCS) on postoperative neurocognitive complications in older patients. This long-term follow-up of the ongoing trial aims to investigate the effects of perioperative dexmedetomidine-esketamine combination and tDCS on long-term outcomes in older patients after noncardiac surgery.

NCT Number	NCT07576543
Lead Sponsor	Peking University First Hospital Collaborators: Peking University Shenzhen Hospital, Second Affiliated Hospital, Zhejiang University, School of Medicine, Fujian Medical University Union Hospital, The First Affiliated Hospital of Air Force Medicial University, Zhejiang University
Conditions	Older Patients, Surgery, Dexmedetomidine, Esketamine, Transcranial Direct Current Stimulation, Cognitive Function, Survival
Enrollment	1,160 participants
Start Date	2026-06
Primary Completion	2030-06 (estimated)
Study Completion	2031-06 (estimated)
Updated on ClinicalTrials.gov	2026-05-12