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Long-term Follow-up of Dexmedetomidine-esketamine and tDCS for Neurocognitive Complications After Surgery

StatusNot Yet Recruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 5 months later Jun 2030 → Dec 2030
See other at-risk trials from Peking University First Hospital

Record History

See every version on ClinicalTrials.gov ↗

  1. Enrollment increased: 1160 → 1996 participants Show 7 more changesShow less
    • Start date: Jun 2026 to Oct 2026
    • Primary completion pushed from Jun 2030 to Dec 2030
    • Study completion pushed from Jun 2031 to Dec 2031
    • Eligibility criteria expanded, about 19 words
    • Secondary endpoints: details revised at 1 of 1 entry
    • Collaborators revised (5)
    • Publications: details revised at 82 of 84 entries
  2. Study description revisedv2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Neurocognitive complications, mainly delirium and neurocognitive disorders, are common cerebral complications in older patients after surgery and associated with worse long-term outcomes. An ongoing 2×2 factorial trial conducted by the investigators plan to test the effects of perioperative dexmedetomidine-esketamine combination and transcranial direct current stimulation (tDCS) on postoperative neurocognitive complications in older patients. This long-term follow-up of the ongoing trial aims to investigate the effects of perioperative dexmedetomidine-esketamine combination and tDCS on long-term outcomes in older patients after noncardiac surgery.
Trial Details
NCT Number NCT07576543
Lead Sponsor Peking University First Hospital
Collaborators: Peking University Shenzhen Hospital, Second Affiliated Hospital, Zhejiang University, School of Medicine, Fujian Medical University Union Hospital, The First Affiliated Hospital of Air Force Medicial University, First Affiliated Hospital of Zhejiang University
Conditions
(from sponsor)		 Older Patients, Surgery, Dexmedetomidine, Esketamine, Transcranial Direct Current Stimulation, Cognitive Function, Survival
Enrollment 1,996 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov