Clinical Trial

A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)

Study acronym: SOLIS-1
Recruiting Phase 2
View on ClinicalTrials.gov →
Summary
This study is being done to learn about the safety and effects of the study drugs, PF-08653945 and PF-08653944, when given alone or together for weight loss, compared to a placebo (a dummy drug that has no active ingredient in it).
Protocol Amendment History 3 changes
notable Trial sites expanded: 48 -> 65 locations 2026-07-09
critical Recruitment opened 2026-06-11
notable Trial sites expanded: 3 -> 48 locations 2026-06-11
Trial Details
NCT Number NCT07575932
Lead Sponsor Pfizer
Conditions Overweight, Obesity, Overweight and/or Obesity, Overweight or Obesity, Overnutrition, Nutrition Disorders, Nutritional and Metabolic Diseases, Body Weight
Enrollment 872 participants
Start Date 2026-05-11
Primary Completion 2027-08-04 (estimated)
Study Completion 2028-01-05 (estimated)
Updated on ClinicalTrials.gov 2026-07-22