The Impact of Preoperative Statin Therapy and and Its Intensity on Postoperative and Mortality and Morbidity

Statins are among the most widely prescribed drugs worldwide, and their benefits in cardiovascular risk reduction are well established. Beyond lipid lowering, statins exert pleiotropic effects - including anti-inflammatory, antioxidant, and endothelial-stabilizing properties - that have generated longstanding interest in their potential to mitigate perioperative complications. Major surgery provokes a systemic inflammatory response, endothelial activation, and hemodynamic stress that may precipitate myocardial injury, organ dysfunction, and death, particularly in patients with pre-existing cardiovascular disease. Therefore, the aim is to examine the association between preoperative statin therapy and its intensity with postoperative all-cause mortality and days at home alive after major non-cardiac surgery in a large, contemporary, dual center-based cohort.

NCT Number	NCT07575737
Lead Sponsor	Karolinska Institutet
Conditions	Perioperative Care
Enrollment	70,000 participants
Start Date	2024-05-14
Primary Completion	2026-02-02 (estimated)
Study Completion	2026-02-02 (estimated)
Updated on ClinicalTrials.gov	2026-05-13