The Effect of Lipedema on Knee Osteoarthritis

This study will be one of the few to examine the effect of lipedema on knee osteoarthritis in a comparative manner with a control group within the same osteoarthritis context. Although the relationship between obesity and osteoarthritis has been extensively studied in the literature, the effect of specific adipose tissue pathologies, such as lipedema, on osteoarthritis has not been sufficiently investigated. This study aims to demonstrate the independent effect of lipedema on osteoarthritis, evaluate clinical and ultrasonographic parameters together, and contribute to early diagnosis and targeted rehabilitation strategies.

NCT Number	NCT07575555
Lead Sponsor	Izmir Democracy University
Conditions	Lipedema, Knee Osteoarthritis, Knee Acute and Chronic Pain, Knee, Knee Arthritis Osteoarthritis, Knee Arthropathy, Knee Cartilage Defects, Knee Cartilage Lesions
Enrollment	76 participants
Start Date	2026-07-07
Primary Completion	2027-07-15 (estimated)
Study Completion	2027-08-15 (estimated)
Updated on ClinicalTrials.gov	2026-07-09