Functional and Affective Effects of a Brief tDCS Intervention in Fibromyalgia and Chronic Fatigue Syndrome

Functional and Affective Effects of a brief tDCS Intervention in Fibromyalgia and Chronic Fatigue Syndrome Fibromyalgia (FM) and chronic fatigue syndrome (CFS) are characterized by persistent, multidimensional symptoms arising from complex brain-body interactions that impair functioning and quality of life. Noninvasive neuromodulation techniques such as transcranial direct current stimulation (tDCS) have been proposed as adjunctive approaches to support short-term functional changes within distributed neural systems, although evidence remains limited and heterogeneous. The objective is to examine immediate pre-post changes in multidimensional clinical outcomes following a standardized tDCS protocol in patients with FM and CFS, and to explore potential diagnosis-related response patterns.

NCT Number	NCT07573709
Lead Sponsor	Hospital Donostia
Conditions	Fibromyalgia (FM), Chronic Fatigue Syndrome (CFS)
Enrollment	20 participants
Start Date	2025-01-01
Primary Completion	2025-05-01 (estimated)
Study Completion	2025-05-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-07