Clinical Evaluation of an Atopic Skin Product Containing Picea Abies Resin Extract

This study evaluates the repairing efficacy of a cosmetic cream containing Picea abies extract compared to a placebo (cream without extract) and a benchmark product. The trial involves 60 healthy subjects (aged 18-60) with atopy-prone and sensitive skin. Over a 21-day period, the primary objective is to measure improvements in skin barrier function via transepidermal water loss (TEWL) and skin moisturization. A dermatologist will also assess soothing effects by evaluating skin dryness, redness, and itching sensations. Secondary objectives include measuring skin inflammation markers (TNFα, TSLP, and TARC) and subject-perceived efficacy through self-assessment questionnaires.

NCT Number	NCT07573592
Lead Sponsor	Repolar Pharmaceuticals Oy Collaborators: Complife Italia Srl, Business Finland
Conditions	Atopy, Skin Barrier to Water Loss
Enrollment	66 participants
Start Date	2026-01-05
Primary Completion	2026-03-18 (estimated)
Study Completion	2026-03-18 (estimated)
Updated on ClinicalTrials.gov	2026-05-07