A Prospective Study of Tumor-specific Tpex in Negative Lymph Nodes for Predicting Pathological Complete Response to Neoadjuvant PD 1 Therapy in Esophageal Cancer

The goal of this observational study is to to determine whether patients with a high proportion of precursor exhausted T cells (Tpex) in negative tumor draining lymph nodes have higher pCR. The main question it aims to answer is: Whether precursor exhausted T cells (Tpex) in negative tumor-draining lymph nodes have better predictive efficacy for treatment response than PD-L1 CPS.

NCT Number	NCT07573397
Lead Sponsor	Fudan University
Conditions	Esophageal Cancer
Enrollment	88 participants
Start Date	2026-05-06
Primary Completion	2028-05-01 (estimated)
Study Completion	2028-08-20 (estimated)
Updated on ClinicalTrials.gov	2026-05-07