The Efficacy and Safety of Temporal Interference Stimulation on Motor Symptoms of Parkinson's Disease

This study aimed to evaluate the clinical efficacy and safety of temporal interference stimulation (TIS) targeting different targets in patients with Parkinson's disease (PD), and to investigate the associated neurophysiological mechanisms. A three-arm, randomised, double-blind, parallel-group design was employed, consisting of a right globus pallidus internus (GPi) stimulation group, a right subthalamic nucleus (STN) stimulation group, and a sham stimulation group. PD patients in the OFF-medication state (≥12 hours after the last dopaminergic dose) were randomly assigned to receive either active TIS targeting the GPi or STN, or sham stimulation, with each session lasting 30 minutes. Clinical symptom assessments were conducted before and immediately after the intervention, and safety was monitored throughout by the research team.

NCT Number	NCT07572903
Lead Sponsor	The First Affiliated Hospital of Anhui Medical University
Conditions	Parkinson s Disease
Enrollment	96 participants
Start Date	2026-05-06
Primary Completion	2026-07-16 (estimated)
Study Completion	2026-08-01 (estimated)
Updated on ClinicalTrials.gov	2026-08-11