Topical Intranasal Anesthetic Block for Reducing the Pain of Botulinum Toxin Injections for Chronic Migraine

People find the injections used in onabotulinumtoxinA (Botox®) uncomfortable. This study will test whether putting a small piece of cotton soaked with 4% lidocaine (a numbing medicine) inside the front of each nostril for 5 minutes before the injections reduces injection pain compared with cotton soaked in saline (salt water).

NCT Number	NCT07571889
Lead Sponsor	Association of Migraine Disorders Collaborators: University Otolaryngology
Conditions	Pain From onabotulinumtoxinA Injections
Enrollment	18 participants
Start Date	2026-03-03
Primary Completion	2027-01 (estimated)
Study Completion	2027-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-06