Colchicine for Autoimmune and Subacute Thyroiditis

Thyroiditis includes inflammatory thyroid disorders such as Hashimoto's thyroiditis and subacute thyroiditis. These conditions may cause thyroid pain, neck tenderness, elevated inflammatory markers, thyroid dysfunction, fatigue, and recurrence. Current management includes observation, symptomatic treatment, nonsteroidal anti-inflammatory drugs, and corticosteroids. Although corticosteroids may be effective, relapse after tapering and treatment-related adverse effects remain limitations. Colchicine is hypothesized to reduce inflammatory activity and may improve biochemical and clinical recovery. This study will evaluate the efficacy and safety of low-dose colchicine compared with corticosteroid therapy and supportive care in adults with autoimmune or subacute thyroiditis.

NCT Number	NCT07571681
Lead Sponsor	Mansoura University Collaborators: Saudi German Hospital - Madinah
Conditions	Hashimoto Thyroiditis, Subacute Thyroiditis, Thyroiditis
Enrollment	300 participants
Start Date	2026-06-15
Primary Completion	2027-07 (estimated)
Study Completion	2027-09 (estimated)
Updated on ClinicalTrials.gov	2026-07-29