Clinical Trial

CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy

Study acronym: CORESTRESS

Recruiting

Record status

This record was last updated May 6, 2026 (before its estimated May 30, 2026 completion). Its status may not reflect the trial's current state.

Summary

This randomized controlled trial evaluates whether intraoperative guidance using the CoreSys monitor reduces the surgical stress response in patients undergoing elective open abdominal hysterectomy. Surgical stress involves complex hemodynamic, endocrine, and inflammatory responses that may negatively impact postoperative recovery. Patients will be randomized to either anesthesia guided by conventional clinical and hemodynamic parameters or anesthesia additionally guided by CoreSys-derived indices of consciousness, nociception, and stress activity. The primary objective is to assess whether CoreSys-guided anesthesia attenuates stress biomarkers, including interleukin-6 (IL-6), cortisol and glycemia.

Trial Details

NCT Number	NCT07571473
Lead Sponsor	Hospital Provincial de Rosario Collaborators: Coresys Health
Conditions	Surgical Stress Response, Inflammation, Anesthesia, Perioperative Care
Enrollment	30 participants
Start Date	2025-01-08
Primary Completion	2026-05-30 (estimated)
Study Completion	2026-05-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-06