Clinical Application of Simcyp-Guided Warfarin Initiation Doses in Cirrhotic Patients With Portal Vein Thrombosis

This was a prospective, open-label, pilot interventional clinical study conducted on Egyptian patients with liver cirrhosis complicated by portal vein thrombosis (PVT) who were indicated for anticoagulation therapy. The study aimed to evaluate the clinical applicability of Simcyp®-guided warfarin initiation doses according to Child-Pugh class, focusing on the time required to achieve a therapeutic INR and the safety of anticoagulation during the initiation phase.

NCT Number	NCT07571460
Lead Sponsor	Kafrelsheikh University
Conditions	Liver Cirrhosis, Portal Vein Thrombosis
Enrollment	21 participants
Start Date	2024-03-15
Primary Completion	2025-03-15 (estimated)
Study Completion	2025-03-15 (estimated)
Updated on ClinicalTrials.gov	2026-05-06