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AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

Study acronym: AMAZE 3
StatusRecruiting
PhasePhase 3
Started2026-05-05
View on ClinicalTrials.gov ↗
This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with excess body weight and obstructive sleep apnoea not treated with positive airway pressure lose weight and improve sleep apnoea. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it) and which treatment participants get is decided by chance.

Amendment history 1 change detected by DataLookout

2026-05-23
notable
Recruitment opened
Trial Details
NCT Number NCT07571005
Lead Sponsor Novo Nordisk A/S
Conditions Obesity, Overweight, Obstructive Sleep Apnoea
Enrollment 300 participants
Start Date 2026-05-05
Primary Completion 2028-07-12 (estimated)
Study Completion 2028-10-04 (estimated)
Updated on ClinicalTrials.gov 2026-07-13