Predicting Response to Immunochemotherapy in Early Triple Negative Breast Cancer

The goal of this clinical trial is to identify cellular and molecular determinants of response to neoadjuvant immunochemotherapy in women aged 18 or older with early-stage triple-negative breast cancer (TNBC). The main questions it aims to answer are: * Can detailed immune profiling of the tumor and its microenvironment predict pathological complete response (pCR, RCB-0) versus partial/non-response (RCB-I, II, III) to neoadjuvant immunochemotherapy? * Are there specific immune or molecular biomarkers (e.g., TILs, CD3/8/20, FoxP3, PDL1, transcriptomic signatures) associated with progression-free survival and overall survival in this population? Researchers will compare patients achieving pCR (RCB-0) to those with residual disease (RCB-I, II, III) to determine if immune and molecular profiles can discriminate responders from non-responders and guide personalized treatment strategies.

NCT Number	NCT07570524
Lead Sponsor	Center Eugene Marquis
Conditions	Triple-negative Breast Cancer (TNBC)
Enrollment	200 participants
Start Date	2026-06-25
Primary Completion	2036-06-25 (estimated)
Study Completion	2036-06-25 (estimated)
Updated on ClinicalTrials.gov	2026-07-10