Quantification of Peripheral Blood iNKTs After Allogeneic Stem Cell Transplantation

The transplantation of allogeneic haematopoietic stem cells (HSCs) can lead to serious complications after transplantation, such as graft-versus-host disease (GvHD), infections and relapse due to immunosuppression. Invariant NKT cells (iNKT cells) play a pivotal role in modulating the immune response and have been demonstrated to be instrumental in the pathogenesis of GvHD, cytomegalovirus (CMV) infection, and relapse. Their levels are associated with the development of these complications. This multicentre study aims to test the feasibility of standardising iNKT cell monitoring and to investigate the association between iNKT cell levels and post-transplant complications.

NCT Number	NCT07570407
Lead Sponsor	University Hospital Pilsen
Conditions	Allogeneic HSCT, Posttransplant Complications, GvHD, Relapse, Acute Myeloid Leukemia
Enrollment	75 participants
Start Date	2026-08-01
Primary Completion	2028-12-31 (estimated)
Study Completion	2029-01-31 (estimated)
Updated on ClinicalTrials.gov	2026-08-13