Individualized Transcranial Magnetic Stimulation in Parkinsonian Disorders

This clinical trial aims to evaluate whether individualized targeted repetitive transcranial magnetic stimulation (rTMS) can improve motor and non-motor symptoms in patients with parkinsonian disorders. The main question it aims to answer is: * Does individualized targeted rTMS alleviate symptoms of parkinsonian disorders? * Which clinical manifestations of parkinsonian syndromes are responsive to individualized targeted rTMS, and to what degree? Procedures: * Preparation (Screening) Participants will undergo clinical assessments, MRI, and EEG before the treatment. * Treatment (2 Weeks) Participants will receive a 10-day TMS treatment (once daily, Monday-Friday). Each treatment day takes approximately 3-4 hours. Participants need to keep stable medications and rehabilitation routines during this time. * Follow-up (10 Weeks) Participants will undergo follow-up assessments at the end of treatment and 10 weeks after treatment. Assessments include clinical scales, MRI, and EEG.

NCT Number	NCT07570212
Lead Sponsor	Peking University First Hospital Collaborators: Changping Laboratory
Conditions	Parkinson's Disease, Multiple System Atrophy, Progressive Supranuclear Palsy
Enrollment	50 participants
Start Date	2025-12-22
Primary Completion	2027-09-22 (estimated)
Study Completion	2027-12-22 (estimated)
Updated on ClinicalTrials.gov	2026-06-29