Effects of Adolescent Synaptic Pruning

The study will use a PET-based measure of brain cell (neuron) connections (synapses) in young adults who have also obtained an MRI, to assess how the loss of brain cell connections (synaptic pruning) is captured by MRI-based measures. This will inform youth MRI studies to understand neurotypical brain development that can help identify abnormal trajectories as in mental illness.

NCT Number	NCT07569718
Lead Sponsor	Beatriz Luna Collaborators: National Institute of Mental Health (NIMH)
Conditions	Healthy Adult Participants, Synaptic Plasticity
Enrollment	60 participants
Start Date	2026-01-09
Primary Completion	2028-06-30 (estimated)
Study Completion	2028-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-06