Increasing CRC Screening in Community Health Centers Through Mobile Messaging Optimization

The goal of this interventional study is to create and test a comprehensive and low burden text message program within existing Community Health Centers (CHC) electronic records system to encourage patients to complete at home colorectal cancer (CRC) screening and to make sure they get follow-up care if their results are abnormal. First, the investigators will learn from clinic staff and patients what their needs and preferences are in terms of use of technology. This information will be used to design the text messages program. * Clinic patients will participate in focus groups * Clinic staff will participate in interviews Second, the investigators will test a series of different message versions in two batches (experiments): * Clinic patients with orders for an at-home colorectal cancer screening kit will receive the different message versions. * In the first batch, the messages that get the most engagement from patients will be selected to be used in the second experiment. * In the second batch, the investigators will test which messages lead to the most colorectal cancer screening completion. * This will be rolled-out within the clinics existing electronic record system. The study team will not receive any information that will identify individual patients. Lastly, the investigators will check again with clinic staff to learn how the program performed, and what would be needed to continue using the text message program in the long run. -Clinic staff will participate in interviews and surveys.

NCT Number	NCT07569250
Lead Sponsor	University of Colorado, Denver Collaborators: National Institutes of Health (NIH), National Cancer Institute (NCI), Massachusetts League of Community Health Centers, Dana-Farber Cancer Institute, University of Texas Southwestern Medical Center, Massachusetts General Hospital
Conditions	Colorectal Cancer
Enrollment	7,220 participants
Start Date	2026-12
Primary Completion	2031-10 (estimated)
Study Completion	2032-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-10