Multi-Site Cortical Puncture for DOR

A multicenter, prospective, randomized controlled clinical trial. The target population consists of patients undergoing IVF/ICSI artificial reproduction who plan to undergo ovarian stimulation and embryo retrieval (DOR) within 4 months. A stratified block randomization method was employed to assign participants in a 1:1 ratio to the intervention group and control group. The study aims to investigate whether multiple-point ovarian cortex puncture during the initial oocyte retrieval procedure improves ovarian reserve and ovarian stimulation outcomes in DOR patients compared to conventional oocyte retrieval techniques.

NCT Number	NCT07568639
Lead Sponsor	First Affiliated Hospital of Guangxi Medical University Collaborators: Nanjing Maternity and Child Health Care Hospital, Qinzhou Maternity and Child Health Care Hospital, The First Affiliated Hospital of Xiamen University, Guigang city People's Hospital, LiuZhou People's Hospital, Nanning Second People's Hospital
Conditions	Diminished Ovarian Reserve (DOR)
Enrollment	214 participants
Start Date	2026-04-30
Primary Completion	2028-03-30 (estimated)
Study Completion	2030-12-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-06