A Prospective Observational Cohort Study Protocol for Disease Severity Stratification and Prognosis Assessment in Patients With Pneumonia

This is a prospective, multicenter observational cohort study involving approximately 2,700 patients, designed to delineate the natural history of pneumonia by tracking the complete clinical course and dynamic multi-omics evolution from the acute phase to recovery; the study aims to quantify severe conversion rates and mortality by comparing baseline characteristics, pathogen distribution, and immune response trajectories between severe and non-severe groups, ultimately revealing the underlying molecular mechanisms of disease progression and optimizing clinical risk stratification strategies.

NCT Number	NCT07567911
Lead Sponsor	Zhonghao Fang Collaborators: Fifth Affiliated Hospital of Guangzhou Medical University
Conditions	Severe Pneumonia, Pneumonia
Enrollment	2,700 participants
Start Date	2026-05-01
Primary Completion	2026-05-01 (estimated)
Study Completion	2028-05-28 (estimated)
Updated on ClinicalTrials.gov	2026-05-05