Clinical Trial

A1-Free vs. Conventional Milk Metabolic Response Study

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Summary
This study will examine how different types of milk affect blood sugar and insulin responses after eating. Specifically, the study compares milk that contains only A2 beta-casein protein (A1-free milk) to conventional milk, which contains both A1 and A2 proteins. Participants will complete four study visits in which they will consume different milk-based beverages. These include lactose-containing milk and lactose-free milk followed by a lactose drink given later. Blood samples will be collected over several hours to measure glucose and insulin responses. Breath tests and questionnaires will also be used to assess digestion and gastrointestinal symptoms. The goal of this study is to determine whether milk protein type influences metabolic responses and whether consuming lactose-free milk affects how the body processes lactose when it is consumed later.
Trial Details
NCT Number NCT07567443
Lead Sponsor Purdue University
Conditions Postprandial Glucose Response, Insulin Response, Lactose Digestion, Postprandial Metabolism
Enrollment 35 participants
Start Date 2026-06-15
Primary Completion 2026-10-31 (estimated)
Study Completion 2027-01-31 (estimated)
Updated on ClinicalTrials.gov 2026-05-05