Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT07567001 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

Name: A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity — clinical trial record (NCT07567001)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: HF-POLARIS

StatusRecruiting

PhasePhase 3

SponsorNovo Nordisk A/S

Started2026-05-11

View on ClinicalTrials.gov ↗

This study is being done to look at the safety and effect of NNC0487-0111 in people with Heart Failure with preserved Ejection Fraction (HFpEF) or Heart Failure with mildly reduced Ejection Fraction (HFmrEF) and excess body weight when compared to placebo. The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have HFpEF or HFmrEF and excess body weight. Participants will get NNC0487-0111 or placebo by injection once a week. Which treatment participants get is decided by chance. NNC0487-0111 is a new medicine that doctors cannot prescribe yet, but it has been tested in people before.

Amendment history 2 changes detected by DataLookout

2026-07-01

Recruitment opened

2026-07-01

Trial sites expanded: 825 → 838 locations

Trial Details

NCT Number	NCT07567001
Lead Sponsor	Novo Nordisk A/S
Conditions	Obesity, Heart Failure
Enrollment	5,610 participants
Start Date	2026-05-11
Primary Completion	2029-07-23 (estimated)
Study Completion	2029-08-15 (estimated)
Updated on ClinicalTrials.gov	2026-08-18