The Finnish Uterine Prolapse Surgery Trial (The Fin-UP Trial)

The goal of this clinical trial is to compare the Manchester procedure and vaginal hysterectomy in treating patients with symptomatic uterine prolapse. The main question it aims to answer is: • What is the difference in the success rates at the the two year follow-up Participants will: * be randomized in either the Manchester procedure or vaginal hysterectomy group and operated as such * visit the clinic at 2 and 5 years after the operation * fill in questionnaires at 1, 2, 5 and 10 years after the operation

NCT Number	NCT07566949
Lead Sponsor	Tampere University Hospital Collaborators: Helsinki University Central Hospital, Turku University Hospital, Kuopio University Hospital, Oulu University Hospital, Hospital Nova, Central Finland
Conditions	Uterine Prolapse, Pelvic Organ Prolapse Vaginal Surgery, Pelvic Organ Prolapse (POP)
Enrollment	426 participants
Start Date	2026-05
Primary Completion	2033-12 (estimated)
Study Completion	2041-12 (estimated)
Updated on ClinicalTrials.gov	2026-05-11