Clinical Trial

Effect of Non-Invasive Vagus Nerve Stimulation in Burn Patients

Enrolling by Invitation
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Summary
This study will evaluate the effects of non-invasive vagus nerve stimulation (nVNS) in adults with burn injuries. Burn patients may experience anxiety, poor sleep quality, pain, itching, and changes in autonomic nervous system function during recovery. Participants will be randomly assigned to one of two groups. The intervention group will receive conventional physiotherapy plus nVNS, and the control group will receive conventional physiotherapy only. Both groups will receive treatment 5 days per week for a total of 10 sessions. nVNS will be applied through electrodes placed on the external ear for 20 minutes per session. Anxiety, sleep quality, pain, itching, and autonomic function will be assessed before and after the treatment period. Autonomic function will be evaluated using heart rate variability measurements. The results will help determine whether nVNS may be a useful supportive method in the rehabilitation of burn patients.
Protocol Amendment History 1 change
critical Primary endpoint(s) modified 2026-05-08
Trial Details
NCT Number NCT07566871
Lead Sponsor Fenerbahce University
Conditions Burn Injury
Enrollment 60 participants
Start Date 2026-05-04
Primary Completion 2026-09 (estimated)
Study Completion 2026-09 (estimated)
Updated on ClinicalTrials.gov 2026-07-07