Clinical Trial

MOTIF@FRESH: Modifying Organisms Transvaginally in Females @ FRESH

Study acronym: MOTIF@FRESH
Not Yet Recruiting Phase 2
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Summary
The MOTIF@ FRESH trial will assess the safety and efficacy of "vaginal microbiome transplantation" (VMT). Healthy females will be enrolled to donate vaginal fluid which will be processed and transplanted in females with a history of recurrent bacterial vaginosis (BV), treated with antibiotics.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-04-28.
Trial Details
NCT Number NCT07566754
Lead Sponsor Douglas Kwon
Collaborators: Massachusetts General Hospital, Bill and Melinda Gates Foundation
Conditions Recurrent Bacterial Vaginosis (BV)
Enrollment 75 participants
Start Date 2026-09
Primary Completion 2027-05 (estimated)
Study Completion 2028-02 (estimated)
Updated on ClinicalTrials.gov 2026-05-18