Cohort Study of PPP Injections for Athletes With Muscle Injury

The investigators hypothesize that a single injection of platelet-poor plasma (PPP) into an acute muscle injury will significantly improve local muscle regeneration and patient outcomes compared to the standard of care using only ultrasound-guided hematoma aspiration. Muscle regeneration will be assessed through quantitative MRI analysis. The investigators anticipate that PPP injections will lead to a measurable reduction in scar tissue and an increase in regenerated muscle tissue at the injury site over a six-month period.

NCT Number	NCT07566039
Lead Sponsor	University of Colorado, Denver Collaborators: Emory University, University of Iowa
Conditions	Lower Extremity Injury
Enrollment	90 participants
Start Date	2026-05-01
Primary Completion	2030-06-01 (estimated)
Study Completion	2030-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-06