Clinical Trial

Effects of Exercise-Induced Muscle Damage on Neuromuscular Complexity

Study acronym: EIMD-NMC
Completed
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Summary
This study will examine the effects of exercise-induced muscle damage, induced by eccentric exercise, on torque production, muscle oxygenation, and electromyographic activity of the knee extensors in healthy young men. Eleven participants will perform a sustained submaximal isometric contraction before and 48 hours after a muscle-damaging eccentric exercise protocol. It is anticipated that the eccentric exercise will confirm the presence of muscle damage, by decrease in maximal voluntary isometric torque, increase in muscle soreness, and reduction in pain-free range of motion. The effect of eccentric exercise on the complexity of torque output, which could be reflected by decreased Sample Entropy and increased DFA α, will be indicated by a possible shift toward more predictable and less adaptable motor control patterns. Based on these results, the investigators will know about the effect of eccentric exercise induced muscle damage on neuromuscular efficiency, that is greater neural input could be required to maintain the same mechanical output, as well as increased oxygen consumption in the active muscle.
Trial Details
NCT Number NCT07565376
Lead Sponsor National and Kapodistrian University of Athens
Conditions Eccentric Exercise, Muscle Damage
Enrollment 11 participants
Start Date 2025-08-20
Primary Completion 2026-01-20 (estimated)
Study Completion 2026-03-30 (estimated)
Updated on ClinicalTrials.gov 2026-05-04