Effect of Zinc Oxide Ointment on Recurrent Aphthous Stomatitis

This randomized placebo-controlled trial evaluated the effectiveness of zinc oxide ointment in the treatment of recurrent aphthous stomatitis (RAS). The study included 100 patients randomly assigned to receive either zinc oxide ointment or a placebo, applied three times daily for six days. Pain intensity was measured using a visual analogue scale (VAS), and oral health-related quality of life was assessed using OHIP-14 at baseline and on days 1, 3, and 6.

NCT Number	NCT07565181
Lead Sponsor	Faculty of Dental Medicine for Girls Collaborators: Cairo University
Conditions	Recurrent Aphthous Stomatitis
Enrollment	100 participants
Start Date	2025-06-30
Primary Completion	2026-01-30 (estimated)
Study Completion	2026-03-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-04