Clinical Trial

Comparative Evaluation of Diclofenac Sodium and Ibuprofen for Post-Endodontic Pain Management

Study acronym: DIPI-PEP
Completed Phase 4
View on ClinicalTrials.gov →
Summary
This randomized controlled trial aims to compare the effectiveness of Diclofenac sodium and Ibuprofen in reducing pain after root canal treatment. Post-endodontic pain is a common complication following treatment of irreversible pulpitis and may affect patient comfort and recovery. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed to manage postoperative dental pain due to their anti-inflammatory and analgesic properties. A total of 60 adult participants diagnosed with irreversible pulpitis involving a single first molar will undergo single-visit root canal therapy. Participants will be randomly assigned to receive either diclofenac sodium 50 mg or ibuprofen 400 mg immediately after treatment. Pain levels will be recorded using a Visual Analogue Scale (VAS) at 6, 12, 24, and 48 hours following treatment. The use of rescue analgesics will also be documented. The study aims to determine which medication provides better pain relief and reduces the need for additional analgesics following endodontic treatment. Findings from this study may help guide clinicians in selecting the most effective medication for postoperative pain management in dental practice.
Trial Details
NCT Number NCT07565012
Lead Sponsor Armed Forces Institute of Dentistry, Pakistan
Conditions Irreversible Pulpitis, Post-endodontic Pain, Root Canal Treatment
Enrollment 60 participants
Start Date 2025-10-01
Primary Completion 2026-03-12 (estimated)
Study Completion 2026-03-25 (estimated)
Updated on ClinicalTrials.gov 2026-05-04