Impact of Novel vs. Usual Brand Menthol Cigarettes on Abuse Liability

This randomized, double-blind, crossover human laboratory study compares the abuse liability of cigarettes containing menthol and non-menthol cigarette variants, using the participant's usual brand menthol cigarette as a within-subject reference. Participants complete standardized laboratory smoking sessions, behavioral economic tasks, and a naturalistic observational period. The study examines differences in nicotine delivery, smoking behavior, and subjective effects across cigarette types in laboratory and real-world contexts.

NCT Number	NCT07564648
Lead Sponsor	Ohio State University Comprehensive Cancer Center Collaborators: National Institute on Drug Abuse (NIDA)
Conditions	Cigarette Addiction, Tobacco Use Disorder
Enrollment	48 participants
Start Date	2026-07-27
Primary Completion	2029-09-30 (estimated)
Study Completion	2029-09-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-22