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Impact of Novel vs. Usual Brand Menthol Cigarettes on Abuse Liability

StatusRecruiting
PhaseNot applicable
Started2026-08-18
View on ClinicalTrials.gov ↗

Amendment history

2026-09-25
notable
Recruitment opened
2026-07-21
minor
Study Status v2
Start date2026-06-22→2026-07-27
2026-06-03
minor
Study Status v1
Start date2026-06-01→2026-06-22
2026-04-27
minor
Original filing
This randomized, double-blind, crossover human laboratory study compares the abuse liability of cigarettes containing menthol and non-menthol cigarette variants, using the participant's usual brand menthol cigarette as a within-subject reference. Participants complete standardized laboratory smoking sessions, behavioral economic tasks, and a naturalistic observational period. The study examines differences in nicotine delivery, smoking behavior, and subjective effects across cigarette types in laboratory and real-world contexts.
Trial Details
NCT Number NCT07564648
Lead Sponsor Ohio State University Comprehensive Cancer Center
Collaborators: National Institute on Drug Abuse (NIDA)
Conditions Cigarette Addiction, Tobacco Use Disorder
Enrollment 48 participants
Start Date 2026-08-18
Primary Completion 2029-09-30 (estimated)
Study Completion 2029-09-30 (estimated)
Updated on ClinicalTrials.gov 2026-09-24