The goal of this clinical trial is to learn if a one-day course of antibiotics after appendectomy surgery works as well as a five-day course to prevent infections in children and adults (aged 10 years and older) with uncomplicated acute appendicitis (non-ruptured, non-gangrenous appendix). The main questions it aims to answer are:
* Does a one-day antibiotic regimen result in a similar rate of surgical site infections, intra-abdominal abscesses, or death within 30 days after surgery compared to a five-day regimen?
* What is the rate of hospital readmission, antibiotic-related side effects, and cost-effectiveness for each treatment duration?
Researchers will compare participants receiving 24 hours of intravenous antibiotics to participants receiving 5 days of antibiotics (1 day intravenous followed by 4 days oral) to see if the shorter course is non-inferior (not meaningfully worse) to the longer standard course.
Participants will:
* Undergo appendectomy for uncomplicated acute appendicitis
* Be randomly assigned to receive either one day or five days of postoperative antibiotics
* Receive follow-up at 30 days after surgery, including a telephone call to check for infections, readmissions, or other complications
* Allow study staff to collect information from their medical records regarding hospital stay, antibiotic side effects, and any need for reoperation or restarting antibiotics