Clinical Trial

RN1701 Injection in the Treatment of Relapsed/Refractory B-Cell Lymphomas

Not Yet Recruiting Early Phase 1
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Summary
This single-arm, open-label pilot study will assess the safety and efficacy of RN1701, a bispecific CD19/CD20-targeted allogeneic CAR-T-cell product, in patients with relapsed or refractory B-cell lymphoma. Up to 19 participants will be enrolled in a conventional 3 + 3 dose-escalation scheme. The primary objective of the study is to evaluate the safety and feasibility of RN1701 for the treatment of relapsed/refractory B-cell lymphoma. The secondary objective is to evaluate the efficacy of RN1701 for the treatment of relapsed/refractory B-cell lymphoma. The exploratory objective is to evaluate the expansion, persistence, and ability of RN1701 to deplete CD19- and/or CD20-positive cells in patients with relapsed/refractory B-cell lymphoma.
Trial Details
NCT Number NCT07563543
Lead Sponsor The First Affiliated Hospital with Nanjing Medical University
Conditions Relapsed/Refractory B-cell Lymphoma
Enrollment 10 participants
Start Date 2026-05-08
Primary Completion 2028-05-30 (estimated)
Study Completion 2028-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-05-04