Effects of Isometric, Isotonic, and Eccentric VMO Exercises in Patellofemoral Pain Syndrome

Patellofemoral pain syndrome (PFPS) is a common musculoskeletal condition characterized by anterior knee pain, especially during activities such as stair climbing, squatting, running, and prolonged sitting. Weakness or delayed activation of the vastus medialis oblique (VMO) muscle is considered an important contributing factor in the development of PFPS. This study aims to compare the effects of three different types of VMO strengthening exercises (isometric, isotonic, and eccentric) applied within the terminal knee extension range (0-30°) on pain, functional performance, and muscle architecture in individuals with PFPS. Participants will be randomly assigned to one of three exercise groups. All participants will receive a standardized physiotherapy program, including heat therapy, TENS, and therapeutic ultrasound, followed by group-specific VMO strengthening exercises. The intervention will be performed three times per week for 8 weeks. Outcomes will be assessed before and after the intervention and will include pain intensity (Visual Analog Scale), functional performance (WOMAC, 30-second sit-to-stand test, and stair test), and muscle architecture parameters measured by ultrasound imaging. The results of this study are expected to provide evidence for optimizing rehabilitation strategies in individuals with PFPS.

NCT Number	NCT07562425
Lead Sponsor	Firat University
Conditions	Patellofemoral Pain Syndrome, Anterior Knee Pain
Enrollment	90 participants
Start Date	2026-08-20
Primary Completion	2026-11-20 (estimated)
Study Completion	2026-11-20 (estimated)
Updated on ClinicalTrials.gov	2026-08-11