Low-Load BFR vs. High-Load Training on Biceps Hypertrophy

This study aimed to compare the effects of low-load blood flow restriction resistance exercise (BFR-RE) performed to voluntary failure with traditional high-load resistance exercise (HL-RE) and a control condition on biceps brachii muscle hypertrophy, muscle stiffness, and maximal strength in untrained young men. Participants completed an 8-week training program, with exercise performed three times per week. Outcomes were assessed using ultrasound imaging, elastography, and one-repetition maximum (1RM) testing. The study evaluates whether low-load BFR training can produce adaptations comparable to high-load resistance training.

NCT Number	NCT07561281
Lead Sponsor	Mehmet Akif Ersoy University Collaborators: Karabuk University
Conditions	Muscle Hypertrophy
Enrollment	33 participants
Start Date	2025-06-01
Primary Completion	2025-08-03 (estimated)
Study Completion	2025-08-03 (estimated)
Updated on ClinicalTrials.gov	2026-05-07