Internuclear Ophthalmoplegia and Multiple Sclerosis: a Multicenter Retrospective Study

Internuclear ophthalmoplegia is a symptom frequently associated with multiple sclerosis (MS), although other etiologies are possible. Some patients do not meet the diagnostic criteria for MS at the time of the internuclear ophthalmoplegia episode but subsequently convert to MS. Studying this specific clinical situation may help enable earlier diagnosis of MS. The objective is to analyze the proportion of patients with isolated internuclear ophthalmoplegia who convert to multiple sclerosis and to identify factors associated with this conversion. The study hypothesis is that the presence of internuclear ophthalmoplegia is highly suggestive of multiple sclerosis, particularly when cerebrospinal fluid-specific oligoclonal bands are present.

NCT Number	NCT07560995
Lead Sponsor	University Hospital, Strasbourg, France
Conditions	Multiple Sclerosis, Internuclear Ophthalmoplegia
Enrollment	200 participants
Start Date	2026-05
Primary Completion	2026-05 (estimated)
Study Completion	2027-05 (estimated)
Updated on ClinicalTrials.gov	2026-05-08