Non-invasive Stimulation of Deep Brain Structures to Modulate Working Memory

A study investigating the effects of non-invasive electrical stimulation of deep brain structures on working memory, attention, and executive functions involved in everyday activities. Currently, there is no effective treatment for impairments in these functions. The study will evaluate the effects of non-invasive electrical stimulation in both healthy older adults and individuals with mild impairment of these functions. The study combines magnetic resonance imaging (MRI) with non-invasive brain stimulation targeting deep brain structures. Its aim is to improve understanding of the neural mechanisms underlying these cognitive functions and their impairments, as well as to explore the mechanisms of non-invasive brain stimulation for potential future therapeutic applications.

NCT Number	NCT07560904
Lead Sponsor	Masaryk University
Conditions	Older Adults (60 - 85 Years Old), Mild Cognitive Impairment (MCI)
Enrollment	70 participants
Start Date	2026-03-01
Primary Completion	2026-07 (estimated)
Study Completion	2026-07 (estimated)
Updated on ClinicalTrials.gov	2026-05-01