Restoring Sinus Rhythm Using Dual-Shock Technique in Patients With Atrial Fibrillation

The goal of this clinical trial is to assess the efficacy and acute safety of the dual electrical cardioversion (ECV) technique compared with the conventional ECV in patients with persistent atrial fibrillation. The main question it aims to answer are: * Is dual ECV more effective than conventional ECV to achieve sinus rhythm restoration? * Is dual ECV safe compared with conventional ECV? * Which are the main factors associated with cardioversion success? Researchers will compare a dual ECV technique with 400J with dual ECV with 200J and conventional ECV. Participants will be randomized to one ECV configuration. The primary efficacy endpoint will be considered the percentage of patients with successful cardioversion with the first shock. The coprimary safety endpoint will be the occurrence of adverse events during ECV.

NCT Number	NCT07560644
Lead Sponsor	Martín Negreira Caamaño, MD, PhD
Conditions	Atrial Fibrillation (AF), Atrial Fibrillation
Enrollment	177 participants
Start Date	2026-08-01
Primary Completion	2027-12-31 (estimated)
Study Completion	2028-02-27 (estimated)
Updated on ClinicalTrials.gov	2026-07-28