Platelet-Rich Plasma Composition and Clinical Effects in Knee Osteoarthritis

This is a prospective, observational cohort study involving 40 patients with primary knee osteoarthritis hospitalized in a rehabilitation hospital in Cluj-Napoca. All participants will receive intra-articular platelet-rich plasma (PRP) injections. The study aims to analyze PRP composition and inflammatory biomarkers to better understand disease mechanisms and evaluate treatment effectiveness.

NCT Number	NCT07558980
Lead Sponsor	Iuliu Hatieganu University of Medicine and Pharmacy
Conditions	Knee Arthritis, Osteoarthritis
Enrollment	40 participants
Start Date	2025-10-15
Primary Completion	2025-11-20 (estimated)
Study Completion	2025-12-20 (estimated)
Updated on ClinicalTrials.gov	2026-04-30