Clinical Trial

Unified Protocol for Emotional Disorders: HiTOP-PRO Trial

Study acronym: UP-HITOP
Recruiting
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Summary
This randomised, parallel-group clinical trial evaluates the effects of the Unified Protocol (UP), a transdiagnostic cognitive-behavioural psychotherapy, on dimensional symptom outcomes aligned with the Hierarchical Taxonomy of Psychopathology (HiTOP) and on related temperamental/personality traits in adults with emotional disorders. Participants are randomly assigned (1:1:1) to UP, treatment as usual (TAU), or a waitlist (WL). Outcomes are assessed at baseline and after approximately 14 weeks. A planned follow-up assessment approximately 3 months after treatment completion is collected in the UP arm only.
Trial Details
NCT Number NCT07557017
Lead Sponsor National Institute of Mental Health, Czech Republic
Conditions Emotional Disorder
Enrollment 90 participants
Start Date 2025-10-08
Primary Completion 2028-04-30 (estimated)
Study Completion 2028-07-31 (estimated)
Updated on ClinicalTrials.gov 2026-04-29