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Amitriptyline for IBS-like Symptoms in Quiescent Crohn's Disease

Name: Amitriptyline for IBS-like Symptoms in Quiescent Crohn's Disease — clinical trial record (NCT07556718)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: AIMS-CD

StatusRecruiting

PhasePhase 2

SponsorUniversity of Michigan

Started2026-06-03

View on ClinicalTrials.gov ↗

Amendment history

2026-06-03

Study Status, Contacts/Locations v1

Recruitment opened

Start dateestimated 2026-04→confirmed 2026-06-03

Study sitesdetails revised at 1 of 1 site

2026-04-22

Original filing

University of Michigan

367 trials monitored

See 20 trials at risk

Crohn's Disease

608 trials monitored

See 27 trials at risk

Many individuals with Crohn's disease continue to experience abdominal pain, bloating, or bowel habit changes even when their inflammation is controlled. Amitriptyline is a medication commonly used at low doses to treat irritable bowel syndrome (IBS) and abdominal pain. This study will assess whether amitriptyline is safe and reduces those ongoing GI symptoms in adults with Crohn's disease in remission.

Trial Details

NCT Number	NCT07556718
Lead Sponsor	University of Michigan Collaborators: The Leona M. and Harry B. Helmsley Charitable Trust
Conditions	Quiescent Crohn's Disease (CD)
Enrollment	100 participants
Start Date	2026-06-03
Primary Completion	2029-12 (estimated)
Study Completion	2029-12 (estimated)
Updated on ClinicalTrials.gov	2026-06-05