Amitriptyline for IBS-like Symptoms in Quiescent Crohn's Disease

Many individuals with Crohn's disease continue to experience abdominal pain, bloating, or bowel habit changes even when their inflammation is controlled. Amitriptyline is a medication commonly used at low doses to treat irritable bowel syndrome (IBS) and abdominal pain. This study will assess whether amitriptyline is safe and reduces those ongoing GI symptoms in adults with Crohn's disease in remission.

NCT Number	NCT07556718
Lead Sponsor	University of Michigan Collaborators: The Leona M. and Harry B. Helmsley Charitable Trust
Conditions	Quiescent Crohn's Disease (CD)
Enrollment	100 participants
Start Date	2026-06-03
Primary Completion	2029-12 (estimated)
Study Completion	2029-12 (estimated)
Updated on ClinicalTrials.gov	2026-06-05