Clinical Practices of Extubation After Invasive Mechanical Ventilation

Extubation is a delicate and complex phase of airway management in anesthesia and critical care. A variety of complications are of concern, ranging from transient hypoxemia to the need for reintubation, which can then become life-threatening for the patient. For this procedure, it may be recommended to use the positive end-expiratory pressure (PEEP) extubation technique to reduce the risks of hypoxemia, atelectasis, and aspiration. However, no specific technique is preferred given the diversity of described procedures (spontaneous ventilation on an auxiliary circuit, PEEP-assisted spontaneous ventilation, adjustment of the APL valve). However, results may vary depending on the patient population (children, adults) and the setting (operating room, intensive care unit). Given the lack of a preferred technique for performing extubation under positive end-expiratory pressure, the aim of this study is to describe the techniques used by healthcare professionals (physicians, nurse anesthetists, nurses) during the extubation of a surgical or intensive care patient.

NCT Number	NCT07554586
Lead Sponsor	Centre Hospitalier Universitaire de Nīmes
Conditions	Mechanical Ventilation, Extubation, Anesthesia, Critical Care, Intensive Care
Enrollment	200 participants
Start Date	2026-04-28
Primary Completion	2026-10 (estimated)
Study Completion	2026-10 (estimated)
Updated on ClinicalTrials.gov	2026-05-04