Clinical Features and Outcomes of VZV CNS Infections

The goal of this observational study is to learn about the clinical characteristics, risk factors, and long-term outcomes of varicella zoster virus (VZV)-related central nervous system (CNS) infections in adults. The main questions it aims to answer are: What are the risk factors associated with VZV meningitis and encephalitis? Which clinical and laboratory findings are associated with complications and poor functional outcomes? Researchers will collect retrospective data from participating centers across the country, including demographic, clinical, laboratory, imaging, and treatment variables. Participants diagnosed with VZV-related central nervous system infections will be followed through medical records, and outcomes such as complications, functional status, and mortality will be evaluated.

NCT Number	NCT07554261
Lead Sponsor	Kocaeli University
Conditions	Varicella Zoster, Varicella Meningitis, Varicella Encephalitis, Varicella Neurological
Enrollment	50 participants
Start Date	2026-04-17
Primary Completion	2026-09-01 (estimated)
Study Completion	2026-09-15 (estimated)
Updated on ClinicalTrials.gov	2026-08-05