Effects of Astragalus Membranaceus on Muscle Function

This study evaluated whether daily supplementation with Astragali radix extract (480 mg/day) for 10 weeks could attenuate training-induced impairments in muscle function, joint pain, and inflammatory markers in moderately active young adults undergoing a structured resistance training program. Participants were randomized in a double-blind, placebo-controlled design to receive either Astragali radix extract (ASTRA) or placebo (PLA) during 8 weeks of progressive resistance training followed by 2 weeks of intensified training. The primary outcome was maximal voluntary isometric torque (MVIT) of the knee extensors. Secondary outcomes included one-repetition maximum (1RM) strength, knee range of motion, muscle soreness (VAS), and circulating blood biomarkers of muscle damage and inflammation.

NCT Number	NCT07552675
Lead Sponsor	University of Pavia
Conditions	Healthy Adult
Enrollment	24 participants
Start Date	2023-09-01
Primary Completion	2025-12-31 (estimated)
Study Completion	2026-02-25 (estimated)
Updated on ClinicalTrials.gov	2026-04-30