Clinical Trial

Cognitive Musical Screening and Therapeutic Innovation in Multiple Sclerosis

Study acronym: MS
Not Yet Recruiting
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Summary
This pilot study evaluates the effectiveness of screening and improving cognitive function in patients with multiple sclerosis (MS) using a musical tool, the Ipsilon. The Ipsilon performance will be compared with established neuropsychological assessments, including the Minimal Assessment of Cognitive Function in MS (MACFIMS) and the Processing Speed Test (PST). Thirty-two participants will be enrolled in a crossover design: half will complete the Ipsilon musical test for 15 minutes daily for seven consecutive days, while the other half will begin with no intervention before switching sequences. Participants will undergo screening for depression, colorblindness, musical background, and upper extremity function. Primary outcomes include evaluating whether the Ipsilon more reliably predicts cognitive domains measured by MACFIMS than the PST and assessing its potential to improve cognitive function. Secondary outcomes will examine associations with work functioning and quality of life.
Trial Details
NCT Number NCT07552428
Lead Sponsor Hunter College of City University of New York
Collaborators: The Cleveland Clinic, Genentech, Inc.
Conditions Multiple Sclerosis
Enrollment 32 participants
Start Date 2026-10-01
Primary Completion 2028-10-01 (estimated)
Study Completion 2028-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-04-27